Planktic foraminiferal analysis, including species populations, diversity trends, high-stress indices and stable isotopes of the latest Campanian through Maastrichtian in the South Atlantic, Tethys and Indian oceans reveal four major climate and faunal events that ended with the Cretaceous-Paleogene (K/Pg), formerly Cretaceous-Tertiary (K/T), mass extinction. The prelude to these events is the late Campanian cooling that reached minimum temperatures in the earliest Maastrichtian (base C31r) correlative with low primary productivity and species diversity. Event-1 begins during the persistent cool climate of the early Maastrichtian (lower C31r) when primary productivity rapidly increased accompanied by rapid species originations, attributed to increased nutrient influx from increased upwelling, erosion during the sea-level fall ~70.6 Ma, and Ninety East Ridge volcanism. During Event-2 (upper C31r to lower C30n), climate rapidly warmed by 2–3 °C in deep waters and peaked at 22 °C on land, primary productivity remained high and diversification reached maximum for the entire Cretaceous. We attribute this climate warming to intense Ninety East Ridge volcanic activity beginning ~69.5 Ma, accompanied by rapid reorganization of intermediate oceanic circulation. Enhanced greenhouse conditions due to the eruption of Deccan Phase-1 in India resulted in detrimental conditions for planktic foraminifera marking the end of diversification. Global cooling resumed in Event-3 (C30n), species diversity declined gradually accompanied by dwarfing, decreased large specialized species, increased small ecologically tolerant taxa, and ocean acidification. Event-3 is mainly the result of enhanced weathering and volcanogenic CO2 adsorption by the oceans during the preceding warm Event-2 that led to cooling and lower pH in the surface ocean. Event-4 marks the last 250 kyr of the Maastrichtian (C29r), which began with the largest Deccan eruptions (Phase-2) that caused rapid climate warming of 4 °C in deep waters and 8 °C on land, acid rain and ocean acidification leading to a major carbonate crisis preceding the K/T mass extinction.  PDF